Sara Khan started her career as a model. She auditioned and made her acting debut with the popular Star Plus' show Sapna Babul Ka...Bidaai (2007-2010) as Sadhna in the main lead opposite Angad Hasija for the past 4 years until she quit the show in June 2010 which remarked the end of her character.
In 2013, Sara made her entry in the Life OK serial Junoon - Aisi Nafrat Toh Kaisa Ishq playing the main antagonist as Shaalu Pandey.
In 2008, she appeared as a star contestant on the show Kya Aap Paanchvi Pass Se Tez Hain?, along with Parul Chauhan who plays her onscreen sister in Sapna Babul Ka...Bidaai.
In 2013, Sara appeared in Life OK's Welcome - Baazi Mehmaan-Nawaazi Ki as contestant and later went to host the show BIG Fame Star. She also appeared in Nach Baliye 6 along with Paras Chhabra as a guest. In December 2014, Khan was seen in Ekta Kapoor's Box Cricket League. She also appeared in two comedy shows Comedy Classes and Comedy Nights Bachao. In 2018, Sara appeared in a Hindi music video Tere Jism with Angad Hasija.