Anupam Kher played a retired middle-class man who loses his son in Saaransh. Kher said that he lost his hair at a young age, and thus, his first role was playing a 65-year-old at the age of 29. Subsequently, he hosted TV shows such as Say Na Something To Anupam Uncle, Sawaal Dus Crore Ka, Lead India, and The Anupam Kher Show - Kucch Bhi Ho Sakta Hai.
He has starred alongside Shah Rukh Khan in many films such as Darr (1993), Zamaana Deewana (1995), Dilwale Dulhaniya Le Jayenge (1995), Chaahat (1996), Kuch Kuch Hota Hai (1998), Mohabbatein (2000), Veer-Zaara (2004), Jab Tak Hai Jaan (2012), and Happy New Year (2014).
Kher is known internationally for Bend It Like Beckham (2002), Bride and Prejudice (2004), The Mistress of Spices (2006) and Lust, Caution (2007), Speedy Singhs (2011), and TV show ER. In 2012, he co-starred in the Academy Award-winning Silver Linings Playbook.
In 2007, Anupam Kher and Satish Kaushik, who studied togher at NSD, started a film production company, Karol Bagh Productions. Their first film, Tere Sang, was directed by Satish Kaushik.
In 2011, he starred alongside Mohanlal and Jayaprada in the Malayalam language romantic drama Pranayam. Kher chose Pranayam as one of the seven best films of his career. In 2009, Kher voiced Carl Fredricksen in the Hindi-dubbed version of the Disney-Pixar animated film Up.
In 2014, Kher starred in the British film Shongram, a fictional romantic drama set during the 1971 Bangladesh Liberation War.In 2019, Kher starred as the former Indian Prime minister Manmohan Singh in the political, biographical drama film The Accidental Prime Minister.
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