Rasika Dugal started appearing in Bollywood movies in 2007. She appeared in Anwar in a character role. She made her debut in Bollywood in the movie Tahaan in 2008. She did a cameo in famous web series by TVF Permanent Roommates Season 2 Episode 4 "The Dinner". She has also appeared as a lead actress in another of TVF's web series Humorously Yours (2017).

She also appeared in YRF TV serial Kismat as Lubna opposite to Rahul Bagga.

She did a cameo in the film Tu Hai Mera Sunday released in 2017 now available on Netflix which starred actors Barun Sobti, Vishal Malhotra, Shahana Goswami, Nakul Bhalla, Avinash Tiwary, Jay Upadhyay.

She won the Best Actor Award for her role in the film Hamid at Rajasthan International Film Festival.

She stars in Mirzapur, a web television series on Amazon Prime Video as Beena Tripathi, Kaleen Bhaiya’s second wife and Munna’s stepmother.

She essays the role of Nutan Yadav, an ambitious politician's daughter willing to sacrifice his daughter's dreams for his political career, in Zoya Akhtar's web series Made in Heaven, released on Amazon Prime on March 8, 2019.

She portrays the role of young IPS officer named as Neeti Singh in Delhi Crime (TV series) released on Netflix on March 21, 2019.